Description

4-(3-Nitrophenoxy)Benzenesulfonyl Chloride is a specialized aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its dual functional groups, which allow for selective reactions to construct complex molecular architectures. This high-purity intermediate is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, especially sulfonamide-based molecules with targeted biological activity.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and insecticides where the sulfonyl chloride moiety is integral to the active compound.
• Material Science: Building block for creating specialized polymers, dyes, and liquid crystals with specific electronic or optical properties.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme function and protein interactions.
• Cross-Coupling Reactions: Serves as an electrophilic coupling partner in palladium-catalyzed and other metal-mediated cross-coupling syntheses.
• Sulfonamide Library Synthesis: A crucial reagent for high-throughput and combinatorial chemistry to generate diverse sulfonamide libraries for screening.

Basic Information

Product Name	4-(3-Nitrophenoxy)Benzenesulfonyl Chloride
CAS No.	1351619-22-1
Molecular Formula	C12H8ClNO5S
Molecular Weight	313.71 g/mol
Synonyms	1-(3-Nitrophenoxy)-4-(chlorosulfonyl)benzene; 4-(3-Nitrophenoxy)benzenesulfonyl chloride; Benzenesulfonyl chloride, 4-(3-nitrophenoxy)-; 3-Nitrophenyl 4-(chlorosulfonyl)phenyl ether; 4-(3-Nitro-phenoxy)-benzenesulfonyl chloride; p-(3-Nitrophenoxy)benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 4-(3-Nitrophenoxy)Benzenesulfonyl Chloride is manufactured under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.