Description

Protac Er Degrader-2 is a potent and selective small molecule degrader designed for targeted protein degradation research. This compound is a critical tool for investigating the PROTAC (Proteolysis Targeting Chimera) mechanism and its application in drug discovery, particularly for challenging therapeutic targets. It is essential for pharmaceutical R&D, academic research institutions, and biotechnology companies focused on oncology, neurodegenerative diseases, and novel therapeutic modalities.

Application

• PROTAC Mechanism Research: A fundamental tool for studying the principles of targeted protein degradation, including ternary complex formation and ubiquitin-proteasome system engagement.
• Oncology Drug Discovery: Used in preclinical research to validate and degrade estrogen receptor (ER) targets, exploring new pathways for cancer therapy.
• Chemical Biology Studies: Employed to probe protein function, understand signaling pathways, and identify synthetic lethal interactions in disease models.
• Degrader Optimization: Serves as a reference compound or starting point for the design and synthesis of next-generation PROTAC molecules with improved properties.
• In Vitro & Cellular Assays: Utilized in high-throughput screening and functional assays to measure degradation efficiency, selectivity, and downstream biological effects.

Basic Information

Item	Details
Product Name	Protac Er Degrader-2
CAS No.	1351169-29-3
Molecular Formula	C31H34F3N5O5S
Molecular Weight	645.70 g/mol
Synonyms	PROTAC ER Degrader-2; ARV-471; Vepdegestrant; (S,E)-N-(4-(3-(4-(2-(2,6-Difluorophenoxy)ethoxy)phenyl)-3-(4-fluorophenyl)acryloyl)piperazin-1-yl)-2-((4-(4-methylthiazol-5-yl)benzyl)oxy)acetamide; ARV471; Vepdegestrant (ARV-471); CC-94676
EINECS	Contact for details

Quality Control

Our Protac Er Degrader-2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with research-grade standards. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.