Description

Protac Rar Degrader-1 is a potent and selective small molecule degrader designed for targeted protein degradation (TPD) research. This compound is a critical tool for investigating the role of the retinoic acid receptor (RAR) in cellular pathways and disease models, offering a novel approach beyond traditional inhibition. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, dermatology, and novel therapeutic modality development. Its mechanism enables the study of protein function loss and validation of new drug targets.

Application

• Targeted Protein Degradation (TPD) Research: A core chemical probe for studying PROTAC (Proteolysis Targeting Chimera) technology and degrader efficacy.
• Oncology R&D: Investigation of RAR's role in cancer cell proliferation, differentiation, and apoptosis for potential cancer therapeutics.
• Chemical Biology Studies: Used to elucidate specific protein functions and validate RAR as a therapeutic target in various disease contexts.
• Drug Discovery Platforms: Serves as a reference compound or starting point for the development of novel RAR-targeting degraders with improved properties.
• Dermatology Research: Exploration of RAR pathways in skin biology and related disorders.
• Mechanism of Action (MoA) Studies: Tool compound for understanding the kinetics and consequences of targeted protein degradation versus inhibition.

Basic Information

Product Name	Protac Rar Degrader-1
CAS No.	1351169-27-1
Molecular Formula	C31H34F2N6O6
Molecular Weight	624.64 g/mol
Synonyms	PROTAC RAR Degrader-1; RAR Degrader-1; ARV-771; (S,R,S)-AHPC-PEG4-VNL; (S,R,S)-AHPC-PEG4-C6-VNL; VNL-PEG4-(S,R,S)-AHPC; VHL Ligand-Linker Conjugates; E3 Ligase Ligand-Linker Conjugate 24; Degrader of Retinoic Acid Receptor
EINECS	Contact for details

Quality Control

Every batch of Protac Rar Degrader-1 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and biological activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for HPLC purity, NMR confirmation, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, keep under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.