Description

Tubacin CAS NO 1350555-93-9 is a potent and selective small molecule inhibitor of histone deacetylase 6 (HDAC6). This compound is a critical research tool for investigating the role of HDAC6 in cellular processes such as protein aggregation, cell motility, and immune synapse regulation. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurodegenerative diseases, and immunology.

Application

• Biomedical Research: A key reagent for studying HDAC6-specific biology, including its function in microtubule dynamics, chaperone-mediated autophagy, and the degradation of misfolded proteins.
• Drug Discovery & Target Validation: Used in high-throughput screening and as a pharmacological probe to validate HDAC6 as a therapeutic target in various disease models.
• Oncology Research: Investigation of HDAC6's role in cancer cell proliferation, metastasis, and the tumor microenvironment, supporting the development of novel anti-cancer therapies.
• Neurodegenerative Disease Studies: Research into conditions like Alzheimer's and Huntington's disease, where HDAC6 inhibition has shown potential in clearing toxic protein aggregates.
• Immunology and Inflammation: Exploration of HDAC6 function in immune cell activation and inflammatory pathways.
• Chemical Biology: Serves as a reference compound for structure-activity relationship (SAR) studies and the design of next-generation HDAC inhibitors.

Basic Information

Product Name	Tubacin
CAS No.	1350555-93-9
Molecular Formula	C₂₁H₂₀N₄O₃S
Molecular Weight	408.47 g/mol
Synonyms	Tubacin; HDAC6 Inhibitor, Tubacin; (2E)-N-Hydroxy-3-[1-[[4-[(2-hydroxyethyl)(methyl)amino]phenyl]sulfonyl]-1H-pyrrol-3-yl]-2-propenamide; AGK2 analogue; HDAC6 Inhibitor IV; Tubastatin A analogue; CAY10603
EINECS	Contact for details

Quality Control

Our Tubacin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.