Description

4-Bromo-2,5-difluoropyridine is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique reactivity profile, where the bromine and fluorine substituents offer distinct sites for selective cross-coupling and functional group transformations. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the construction of complex heterocyclic molecules, such as active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Serves as a backbone for creating specialized ligands used in transition metal catalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or fluorinated polymers.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring regioselectively functionalized pyridine cores.

Basic Information

Product Name	4-Bromo-2,5-difluoropyridine
CAS No.	1349718-16-6
Molecular Formula	C5H2BrF2N
Molecular Weight	193.98 g/mol
Synonyms	2,5-Difluoro-4-bromopyridine; 4-Bromo-2,5-difluoropyridine; Pyridine, 4-bromo-2,5-difluoro-; 1349718-16-6; 4-Br-2,5-F2Py
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2,5-difluoropyridine is manufactured under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring traceability and consistency for your critical R&D and scale-up processes. Our quality commitment supports compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container must be kept tightly closed in a dry and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.