Description

Gsk 343 is a potent and selective small molecule inhibitor of the Enhancer of Zeste Homolog 2 (EZH2) methyltransferase, a key component of the Polycomb Repressive Complex 2 (PRC2). This compound is a critical research tool for investigating epigenetic regulation, cellular differentiation, and oncogenesis. It is primarily utilized by researchers and scientists in the fields of academic research, pharmaceutical R&D, and biotechnology for target validation and mechanistic studies in cancer and other diseases.

Application

• Epigenetics Research: A key tool for studying histone methylation dynamics, specifically the inhibition of H3K27 trimethylation.
• Cancer Biology Studies: Used to investigate the role of EZH2 in tumor progression, proliferation, and metastasis in various cancer cell lines and models.
• Drug Discovery & Development: Serves as a reference compound and pharmacological probe for screening and developing novel EZH2-targeted therapeutics.
• Stem Cell & Developmental Biology: Applied to understand the epigenetic mechanisms controlling cell fate decisions, pluripotency, and differentiation.
• Biochemical Assays: Used in in vitro enzymatic assays to characterize EZH2 activity and inhibitor potency.

Basic Information

Product Name	Gsk 343
CAS No.	1346704-33-3
Molecular Formula	C30H30N4O3
Molecular Weight	494.59 g/mol
Synonyms	GSK343; GSK-343; 1-[(4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-3-[(E)-3-[4-(2-hydroxypropan-2-yl)phenyl]prop-2-enoyl]-4-methyl-1,3-dihydro-2H-imidazol-2-one; (E)-1-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(3-(4-(2-hydroxypropan-2-yl)phenyl)acryloyl)-4-methyl-1H-imidazol-2(3H)-one; EZH2 Inhibitor GSK343
EINECS	Contact for details

Quality Control

Our Gsk 343 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure high batch-to-batch consistency and reliability for research applications. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.