Description

2-[(3R)-3-(2,3,4,5,6-Pentadeuteriophenyl)-3-[4-(Trifluoromethyl)Phenoxy]Propyl]Isoindole-1,3-Dione is a high-purity, deuterium-labeled advanced pharmaceutical intermediate. This compound is specifically designed for use in drug discovery and development, offering enhanced metabolic stability and traceability in pharmacokinetic studies. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors requiring isotopically labeled building blocks for novel active pharmaceutical ingredients (APIs).

Application

• Deuterated Pharmaceutical Intermediate: A critical building block for synthesizing deuterium-labeled drug candidates, leveraging the deuterium kinetic isotope effect (DKIE) to improve metabolic profiles.
• Metabolic Pathway Tracer: Used in mass spectrometry-based studies to track and quantify drug metabolites in biological systems for ADME (Absorption, Distribution, Metabolism, and Excretion) research.
• Internal Standard for Bioanalysis: Serves as a high-quality internal standard in LC-MS/MS methods for the accurate quantification of non-labeled parent compounds in complex matrices like plasma or tissue.
• Proteomics & Chemical Biology Research: Employed in the synthesis of chemical probes for studying protein-ligand interactions and enzyme mechanisms.
• Process Chemistry & Scale-up: Supports the development and optimization of synthetic routes for novel therapeutics in process R&D laboratories.

Basic Information

Product Name	2-[(3R)-3-(2,3,4,5,6-Pentadeuteriophenyl)-3-[4-(Trifluoromethyl)Phenoxy]Propyl]Isoindole-1,3-Dione
CAS No.	1346617-46-6
Molecular Formula	C24H10D5F3NO3
Molecular Weight	Contact for details
Synonyms	(3R)-3-(2,3,4,5,6-Pentadeuteriophenyl)-3-[4-(Trifluoromethyl)phenoxy]propyl]phthalimide; 2-[(3R)-3-(Pentadeuteriophenyl)-3-[4-(Trifluoromethyl)Phenoxy]Propyl]-1H-Isoindole-1,3(2H)-Dione; Deuterated N-[(3R)-3-(4-Trifluoromethylphenoxy)-3-phenylpropyl]phthalimide; (R)-N-[3-(4-Trifluoromethylphenoxy)-3-(pentadeuteriophenyl)propyl]phthalimide; Deuterium-labeled Phthalimide Derivative CAS 1346617-46-6
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques to confirm identity, isotopic purity, and chemical purity. Certificates of Analysis (COA) detailing specifications for assay, isotopic enrichment, and impurity profiles are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content, MS)	≥ 98 atom % D
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.