Description

Z,Z-Dienestrol-D2 is a deuterium-labeled internal standard of dienestrol, widely used in quantitative bioanalysis and mass spectrometry-based assays. It provides exceptional analytical precision and accuracy for the measurement of endogenous or exogenous dienestrol in complex biological matrices. This compound is essential for pharmaceutical research, clinical toxicology laboratories, and regulatory compliance testing where isotopic dilution mass spectrometry (IDMS) is required. Researchers and contract research organizations (CROs) engaged in hormone metabolism studies, forensic screening, and drug development rely on its high isotopic purity and structural fidelity.

Application

• Internal standard for LC-MS/MS quantification of dienestrol in plasma, serum, and urine
• Reference material in method validation for steroid hormone assays per FDA Bioanalytical Method Validation Guidance
• Quality control standard in clinical toxicology and anti-doping laboratories
• Calibration standard for pharmacokinetic and metabolite profiling studies
• Supporting tool in reproductive endocrinology research and estrogenic activity assessment
• Use in regulatory submissions requiring isotopically labeled reference standards (ICH M10)
• Stable isotope tracer in mechanistic studies of estrogen receptor binding and metabolism
• Key reagent for certified reference material (CRM) production under ISO 17034

Basic Information

Product Name	Z,Z-Dienestrol-D2
CAS No.	1346606-45-8
Molecular Formula	C18H18D2O2
Molecular Weight	270.36 g/mol
Synonyms	Z,Z-Dienestrol-d2; (Z,Z)-Dienestrol-2,2-d2; 3,4-Bis(4-hydroxyphenyl)-3-hexene-2,5-dione-d2; 3,4-Bis(p-hydroxyphenyl)-cis,cis-3-hexene-2,5-dione-d2; Diethylstilbestrol-d2 (Z,Z-isomer); DES-d2 (Z,Z); (Z,Z)-3,4-Bis(4-hydroxyphenyl)-3-hexene-2,5-dione-2,2-d2; 2,2-Dideutero-Z,Z-dienestrol
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. Each batch is verified for isotopic enrichment (>98% D at designated positions), chemical purity (≥99.0% by HPLC), identity (NMR and IR confirmation), and absence of critical impurities. Manufacturing and testing follow ISO 9001-certified processes, and materials are compliant with REACH and ICH Q5C guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Due to its hygroscopic nature, minimize exposure to ambient humidity and avoid repeated opening of the container. Keep desiccated and handle in a controlled environment with low relative humidity (<30% RH).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Confirms deuterium labeling position and stereochemistry (Z,Z)
Assay (HPLC)	≥99.0%
Isotopic Purity (MS)	≥98% D at C-2 position
Residual Solvents (GC)	Meets ICH Q3C limits
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.