Description

3-Carboxy Detomidine-13C,15N2 is a stable isotope-labeled analog of the veterinary sedative detomidine, specifically enriched with carbon-13 and nitrogen-15 isotopes. This compound is essential for conducting precise and reliable quantitative mass spectrometry analysis in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in veterinary medicine and drug development who require high-purity internal standards for LC-MS/MS applications.

Application

• Internal Standard for Bioanalysis: Serves as a critical reference compound in the quantitative LC-MS/MS analysis of detomidine and its metabolites in biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug concentration over time in animal models, supporting ADME (Absorption, Distribution, Metabolism, Excretion) research.
• Metabolite Identification and Profiling: Aids in the detection and structural elucidation of detomidine metabolites through stable isotope dilution techniques.
• Veterinary Drug Research: Supports method development and validation for the analysis of sedative residues in food-producing animals to ensure food safety compliance.
• Quality Control in Reference Standard Production: Used in the calibration and verification of analytical methods for the certification of detomidine reference standards.
• Regulatory Submissions: Provides the data integrity required for studies submitted to agencies like the FDA and EMA for veterinary drug approval.

Basic Information

Product Name	3-Carboxy Detomidine-13C,15N2
CAS No.	1346605-14-8
Molecular Formula	C13H16N2O2 (with 13C and 15N2 labeling at specified positions)
Molecular Weight	Contact for details
Synonyms	Detomidine-13C,15N2 Carboxylic Acid; 4-[5-(13C,15N2)Imidazolyl]methyl]benzoic Acid; 1H-Imidazole-4-methanamine, N-(2,3-dimethylphenyl)-, 13C,15N2-labeled, 4-carboxy derivative; Stable Isotope Labeled Detomidine Metabolite; 13C,15N2-Detomidine Carboxylic Acid; Isotopic Internal Standard for Detomidine; [13C,15N2]-3-Carboxy Detomidine
EINECS	Contact for details

Quality Control

Our 3-Carboxy Detomidine-13C,15N2 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment, and purity. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to expected mass spectrum
Purity (HPLC)	≥ 95% (Area Percent)
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chemical Purity	≥ 98% (by NMR)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.