Description

Adefovir-D4 Diphosphate Triethylamine Salt is a high-purity, isotopically labeled salt form of the antiviral drug adefovir, specifically designed for advanced analytical and research applications. This deuterated compound is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolic studies, providing an indispensable internal standard for mass spectrometry. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical chemists engaged in drug development and bioanalytical method validation for antiviral agents.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering reference standard for the precise quantification of adefovir and its metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development and Validation: Used to establish robust, sensitive, and specific HPLC or UPLC methods compliant with FDA and ICH guidelines.
• Stable Isotope Labeling Studies: Facilitates mechanistic studies of metabolic pathways and degradation products due to its deuterium (D4) labeling.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for adefovir dipivoxil drug substances and finished products.
• Reference Material for Certified Standards: Acts as a starting material for the preparation of certified reference materials (CRMs) with metrological traceability.

Basic Information

Product Name	Adefovir-D4 Diphosphate Triethylamine Salt
CAS No.	1346604-40-7
Molecular Formula	C14H22D4N5O8P2 • C6H15N
Molecular Weight	Contact for details
Synonyms	9-[2-(Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl]adenine-d4 Diphosphate Triethylamine Salt; PMEA-d4 Diphosphate TEA Salt; GS-0393-d4 (Diphosphate Salt); [[2-(6-Amino-9H-purin-9-yl)ethoxy-d4]methyl]phosphonic Acid Diphosphate Triethylamine Salt; Adefovir-d4 Bis(Pivaloyloxymethyl) Ester Diphosphate Triethylamine Salt; Deuterated Adefovir Dipivoxil Diphosphate TEA Salt
EINECS	Contact for details

Quality Control

Our Adefovir-D4 Diphosphate Triethylamine Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical and isotopic purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, residual solvents, and heavy metals, ensuring compliance with research and development standards. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium, D4)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.