Description

1-Methyl-2-Phenyl-5-[[1-Phenylpropan-2-Yl(Trideuteriomethyl)Amino]Methyl]-4-Propan-2-Ylpyrazol-3-One CAS NO 1346601-05-5 is a specialized deuterated pyrazolone derivative, a high-value intermediate designed for advanced research and development. This compound is critical for applications requiring isotopic labeling, offering enhanced metabolic stability and traceability in pharmacokinetic and mechanistic studies. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on developing novel therapeutic agents and analytical standards.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of deuterated drug candidates for improved metabolic profiles.
• Metabolic Tracer: Used in mass spectrometry and NMR-based studies to track drug absorption, distribution, metabolism, and excretion (ADME).
• Mechanistic Probe: Enables the investigation of reaction pathways and enzyme mechanisms in medicinal chemistry research.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Isotope-Labeled API Synthesis: Employed in the production of active pharmaceutical ingredients (APIs) with deuterium incorporation for patent extension and new drug applications.
• Biochemical Research: Utilized in studies exploring protein-ligand interactions where isotopic labeling is required.

Basic Information

Item	Detail
Product Name	1-Methyl-2-Phenyl-5-[[1-Phenylpropan-2-Yl(Trideuteriomethyl)Amino]Methyl]-4-Propan-2-Ylpyrazol-3-One
CAS No.	1346601-05-5
Molecular Formula	C24H29D3N3O
Molecular Weight	375.55 g/mol
Synonyms	Deuterated Pyrazolone Derivative; 1-Methyl-2-phenyl-5-{[1-phenylpropan-2-yl(trideuteriomethyl)amino]methyl}-4-(propan-2-yl)-1H-pyrazol-3(2H)-one; 4-Isopropyl-1-methyl-2-phenyl-5-{[1-phenylpropan-2-yl(trideuteriomethyl)amino]methyl}-1,2-dihydro-3H-pyrazol-3-one; (CD3)-Labeled Pyrazolone Intermediate; CAS 1346601-05-5
EINECS	Contact for details

Quality Control

Our deuterated chemical intermediates are produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C, and deuterium), HPLC, and mass spectrometry, to confirm isotopic purity, chemical identity, and overall purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium NMR/MS)	≥ 98 atom % D
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.