Description

Nordihydro Guaiaretic Acid-D6 is a deuterated isotopologue of the naturally occurring lignan, Nordihydroguaiaretic Acid (NDGA), where six hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring high accuracy and precision in analytical measurements. It is critically required by pharmaceutical, biotechnology, and academic research laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and metabolic pathway research.

Application

• Internal Standard for LC-MS/MS: Primary application as a quantitative reference standard in Liquid Chromatography-Tandem Mass Spectrometry for the analysis of Nordihydroguaiaretic Acid and its metabolites.
• Drug Metabolism Studies (DMPK): Used in pharmacokinetic and bioavailability studies to track the parent compound's fate in biological systems with minimal interference.
• Biomedical Research: Facilitates precise quantification in research investigating the biological activities, such as antioxidant or anti-inflammatory effects, of NDGA.
• Bioanalytical Method Development: Critical for validating robust and reliable analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Metabolomics and Proteomics: Enables accurate relative and absolute quantification in complex 'omics' studies to understand biochemical pathways.
• Quality Control & Assurance: Employed in GMP/GLP environments to ensure the accuracy and consistency of analytical results for pharmaceutical products.

Basic Information

Product Name	Nordihydro Guaiaretic Acid-D6
CAS No.	1346600-58-5
Molecular Formula	C18H16D6O4
Molecular Weight	308.40 g/mol
Synonyms	NDGA-d6; 4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]-d6; 1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane-d6; meso-Nordihydroguaiaretic Acid-d6; (±)-Nordihydroguaiaretic Acid-d6; Larreaic Acid-d6; 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol-d6
EINECS	Contact for details

Quality Control

Every batch of Nordihydro Guaiaretic Acid-D6 is manufactured and analyzed under strict quality systems. We provide comprehensive analytical data to support its use in regulated environments. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and analytical method results (e.g., HPLC, NMR, MS) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.