Description

2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinemethanol-D5 is a deuterated analog of a key quinoline-based intermediate, offering a stable isotopic label for advanced research and development. This compound is critical for applications requiring precise metabolic and pharmacokinetic studies, providing enhanced analytical sensitivity and reliability. It is primarily utilized by pharmaceutical R&D teams and contract research organizations (CROs) focused on drug discovery and development, particularly for creating deuterated drug candidates and conducting mechanistic studies. The CAS number for this compound is 1346600-49-4.

Application

• Pharmaceutical Research: As a stable isotope-labeled internal standard in LC-MS and GC-MS analysis for accurate quantification of the parent compound in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical agents.
• Deuterated Drug Synthesis: Serves as a key building block in the synthesis of deuterium-labeled drug candidates, which can offer improved metabolic stability and altered pharmacokinetic properties.
• Mechanistic Studies: Enables detailed investigation of reaction pathways and metabolic transformations in both chemical and biological systems.
• Analytical Method Development: Essential for developing and validating highly sensitive and specific bioanalytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Reference Standard: Provides a certified reference material for quality control and assurance in pharmaceutical manufacturing and analytical laboratories.

Basic Information

Product Name	2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinemethanol-D5
CAS No.	1346600-49-4
Molecular Formula	C19H11D5FNO
Molecular Weight	~296.36 g/mol
Synonyms	3-Quinolinemethanol, 2-cyclopropyl-4-(4-fluorophenyl)-, D5-labeled; 2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-methanol-D5; Deuterated 2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinemethanol; (2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methanol-D5; CPFQM-D5; [D5]-2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinemethanol
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems to ensure isotopic purity and chemical integrity. Each batch of 2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolinemethanol-D5 is characterized by advanced spectroscopic techniques (NMR, MS) and undergoes rigorous purity analysis by HPLC to meet exacting research standards. Certificates of Analysis (COA) are provided, detailing isotopic enrichment (D-content), chemical purity, and analytical methods. We support compliance with relevant pharmacopeial and ICH guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.