Description

4-Desmethoxy-4-Bromo Trimethoprim-D3 is a deuterated, brominated derivative of the antibiotic Trimethoprim, specifically designed for use as a high-purity internal standard in analytical chemistry. This compound is critical for ensuring accurate quantification and method validation in complex matrices, providing unmatched reliability for trace-level analysis. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, metabolism research, and quality control of antibiotic formulations.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of Trimethoprim and its metabolites in bioanalytical studies, ensuring data integrity for regulatory submissions.
• Pharmaceutical Research & Development: Used in method development and validation for stability testing, impurity profiling, and pharmacokinetic analysis of antibiotic drugs.
• Metabolite Identification & Tracing: The deuterium (D3) label allows for clear differentiation from endogenous compounds, facilitating advanced metabolism and degradation pathway studies.
• Veterinary Pharmaceutical Analysis: Applied in the quality control and residue testing of antibiotics used in animal health products.
• Environmental Fate Studies: Supports research into the environmental persistence and breakdown products of pharmaceutical compounds.
• Reference Standard for Regulatory Compliance: Serves as a certified reference material for assays requiring compliance with FDA, EMA, and ICH guidelines.

Basic Information

Product Name	4-Desmethoxy-4-Bromo Trimethoprim-D3
CAS No.	1346600-27-8
Molecular Formula	C13H13D3BrN4O3
Molecular Weight	353.19 g/mol (approx.)
Synonyms	4-Bromo-5-[(3,4,5-trimethoxyphenyl)methyl]-2,4-pyrimidinediamine-d3; Trimethoprim-4-Bromo-d3 Derivative; 4-Bromo Trimethoprim Deuterated Standard; 4-Bromo-TMP-d3; Deuterated 4-Bromo Trimethoprim; [2H3]-4-Desmethoxy-4-Bromo Trimethoprim; Internal Standard for Trimethoprim LC-MS
EINECS	Contact for details

Quality Control

Every batch of 4-Desmethoxy-4-Bromo Trimethoprim-D3 is manufactured and analyzed under strict quality systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including HPLC, NMR, and Mass Spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity (by HPLC), isotopic purity (D-content), and residual solvents, ensuring it meets the stringent requirements for use as a reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.