Description

5-[2-[[1,1,1,2,3,3-Hexadeuterio-3-(4-Methoxyphenyl)Propan-2-Yl]Amino]-1-Hydroxyethyl]Benzene-1,3-Diol is a deuterated analog of a key pharmaceutical intermediate, offering enhanced metabolic stability for advanced research and development. This high-purity compound is critical for pharmacokinetic and metabolic studies, providing a stable isotopic label for precise analytical tracking. It is primarily utilized by pharmaceutical R&D teams and analytical laboratories focused on developing and characterizing novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and identification of the parent drug compound in complex matrices.
• Metabolic Pathway Tracing: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the fate of drug molecules using mass spectrometry due to its deuterium labels.
• Deuterated Active Pharmaceutical Ingredient (API) Synthesis: Acts as a key building block in the synthesis of deuterated drug candidates aimed at improving metabolic stability and patent life.
• Internal Standard for Bioanalysis: Essential in LC-MS/MS methods for the accurate bioanalysis of biological samples, correcting for matrix effects and instrument variability.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision quantitative analysis to achieve superior accuracy and precision in clinical and forensic toxicology.
• Research into Drug-Drug Interactions: Facilitates studies on how deuterium substitution affects enzyme inhibition and interaction profiles.

Basic Information

Product Name	5-[2-[[1,1,1,2,3,3-Hexadeuterio-3-(4-Methoxyphenyl)Propan-2-Yl]Amino]-1-Hydroxyethyl]Benzene-1,3-Diol
CAS No.	1346599-77-6
Molecular Formula	C18H19D6NO4
Molecular Weight	337.45 g/mol
Synonyms	Deuterated Formoterol-d6; (R,R)-Formoterol-d6; 5-[2-[[1,1,1,2,3,3-Hexadeuterio-3-(4-Methoxyphenyl)propan-2-yl]amino]-1-hydroxyethyl]benzene-1,3-diol; (R,R)-5-[2-[[1,1,1,2,3,3-Hexadeuterio-3-(4-methoxyphenyl)propan-2-yl]amino]-1-hydroxyethyl]benzene-1,3-diol; Formoterol D6; Formoterol-d6 (hexadeuterated); 1,3-Benzenediol, 5-[2-[[1,1,1,2,3,3-hexadeuterio-3-(4-methoxyphenyl)-2-propanyl]amino]-1-hydroxyethyl]-; Eformoterol-d6
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality management systems to ensure batch-to-batch consistency and high isotopic purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity, isotopic enrichment (D-content), and chromatographic profile. We support compliance with cGMP and ICH guidelines for pharmaceutical development, and specifications can be aligned with client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere (e.g., argon or nitrogen) to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.