Description

Clofedanol-D5 Hydrochloride is a deuterated isotopologue of the antitussive agent clofedanol, specifically labeled with five deuterium atoms. This compound serves as a critical internal standard in quantitative bioanalytical methods, ensuring high accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and regulatory compliance.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of clofedanol and its metabolites in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Used to track drug absorption, distribution, metabolism, and excretion (ADME) with high specificity.
• Metabolite Identification and Profiling: Aids in the structural elucidation and quantification of drug metabolites.
• Bioanalytical Method Development and Validation: Critical for establishing robust, reproducible, and GLP-compliant analytical assays.
• Doping Control Analysis: Potential application in sports anti-doping programs for the accurate detection of clofedanol.
• Forensic Toxicology: Supports the confirmatory analysis of clofedanol in forensic investigations.

Basic Information

Product Name	Clofedanol-D5 Hydrochloride
CAS No.	1346599-66-3
Molecular Formula	C17H15D5Cl2NO
Molecular Weight	328.27 g/mol
Synonyms	Clofedanol-d5 HCl; 2-[(2-Chlorophenyl)(phenyl)methyl]-5-(2-[(2H5)methyl]aminoethyl)-2,2-dimethyl-1,3-dioxolane-4-methanol Hydrochloride; Chlophedianol-D5 Hydrochloride; Detigon-D5 Hydrochloride; Ulone-D5 Hydrochloride; SKF 478-D5 Hydrochloride; Deuterated Clofedanol HCl
EINECS	Contact for details

Quality Control

Our Clofedanol-D5 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm identity, isotopic enrichment (D5, min. 98 atom % D), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); desiccants are recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98 atom % D (D5)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.