Description

Rac 2-Aminothiazoline-4-Carboxylic Acid-13C,15N2 is a stable isotope-labeled analog of 2-aminothiazoline-4-carboxylic acid (ATCA), a key biomarker and intermediate in cyanide exposure and cysteine metabolism studies. This compound is essential for providing the high-purity, isotopically enriched reference material required for accurate quantitative analysis in advanced research and diagnostic applications. It is primarily utilized by analytical laboratories, forensic toxicologists, and pharmaceutical researchers developing detection methods and studying metabolic pathways.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical, non-interfering internal standard for the precise quantification of endogenous ATCA in biological samples (e.g., blood, urine) for forensic and clinical toxicology.
• Biomarker Research for Cyanide Exposure: Enables the development and validation of highly sensitive and specific diagnostic assays to confirm cyanide poisoning.
• Metabolic Pathway Tracing: Used in 13C and 15N isotopic labeling studies to elucidate the detailed metabolic fate of cysteine and related thiazoline compounds.
• Pharmaceutical Reference Standard: Acts as a certified reference material (CRM) for quality control and method validation in pharmaceutical analysis and regulatory submissions.
• Forensic Science Applications: Supports method development in forensic laboratories for post-mortem detection and confirmation of cyanide.
• Stable Isotope Dilution Assays (SIDA): The gold-standard technique for achieving maximum accuracy and precision in quantitative mass spectrometry.

Basic Information

Product Name	Rac 2-Aminothiazoline-4-Carboxylic Acid-13C,15N2
CAS No.	1346599-59-4
Molecular Formula	C313C15N2H6O2S
Molecular Weight	Contact for details
Synonyms	ATCA-13C,15N2; 2-Amino-δ2-thiazoline-4-carboxylic acid-13C,15N2; (±)-2-Aminothiazoline-4-carboxylic Acid-13C,15N2; 2-Amino-4-carboxythiazoline-13C,15N2; 4-Thiazolinecarboxylic acid, 2-amino-, 13C,15N2-labeled; Stable Isotope Labeled ATCA; Cyanide Exposure Biomarker-13C,15N2
EINECS	Contact for details

Quality Control

Every batch of Rac 2-Aminothiazoline-4-Carboxylic Acid-13C,15N2 is manufactured and analyzed under strict quality systems to ensure identity, purity, and isotopic enrichment meet the exacting standards for research and diagnostic use. Comprehensive testing includes HPLC for chemical purity, NMR and MS for structural and isotopic confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) providing batch-specific data, including isotopic purity (atom % 13C and 15N), is supplied with each product.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom %
Isotopic Purity (15N)	≥ 98 atom %
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.