Description

7-[2-Hydroxy(Propyl-D6)]Guanine is a deuterated analog of a key guanine derivative, specifically designed for advanced research and development applications. This compound is valued for its isotopic labeling, which provides enhanced metabolic stability and traceability in analytical studies. It is primarily utilized by pharmaceutical researchers, analytical chemists, and contract research organizations (CROs) engaged in drug metabolism and pharmacokinetics (DMPK) studies, proteomics, and the development of novel diagnostic agents.

Application

• Internal Standard in LC-MS/MS: Serves as a critical, stable isotope-labeled internal standard for the quantitative bioanalysis of guanine-based compounds in biological matrices.
• Drug Metabolism Studies (DMPK): Used as a tracer to investigate the metabolic pathways, bioavailability, and excretion profiles of pharmaceutical candidates.
• Proteomic & Biomarker Research: Employed in mass spectrometry-based proteomics for relative and absolute quantification (AQUA) of proteins and peptides.
• Nucleic Acid Research: Acts as a building block or probe in the study of modified nucleosides, nucleotide chemistry, and epigenetic mechanisms.
• Diagnostic Agent Development: Utilized in the research and development of novel contrast agents or tracers for molecular imaging techniques like PET-MRI.

Basic Information

Product Name	7-[2-Hydroxy(Propyl-D6)]Guanine
CAS No.	1346599-30-1
Molecular Formula	C8H7D6N5O2
Molecular Weight	213.24 g/mol
Synonyms	7-(2-Hydroxypropyl-d6)guanine; 2-Amino-7-[(2-hydroxy-1-methylethyl-d6)]-1H-purin-6(7H)-one; Deuterated HP-Guanine; Guanine, 7-(2-hydroxypropyl-d6)-; 7-(2-Hydroxypropyl-d6)-1H-purin-6-amine; HP-Guanine-d6; [2H6]-7-(2-Hydroxypropyl)guanine
EINECS	Contact for details

Quality Control

Our 7-[2-Hydroxy(Propyl-D6)]Guanine is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (deuterium incorporation), and identity confirmation (by NMR and MS). We adhere to cGMP principles for research chemicals to guarantee batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., argon or nitrogen) after opening to maintain stability and prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.