Description

Belotecan-D7 Hydrochloride is a deuterated isotopologue of the topoisomerase I inhibitor Belotecan, where seven hydrogen atoms are replaced with deuterium. This strategic deuteration is designed to potentially alter the pharmacokinetic and metabolic profile of the parent compound, making it a critical tool for advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists, pharmacologists, and analytical scientists in the pharmaceutical and biotechnology industries for drug metabolism studies (DMPK), tracer analysis, and as a reference standard.

Application

• Internal Standard for Quantitative Analysis: Serves as a high-purity, isotopically labeled internal standard for the accurate quantification of Belotecan and its metabolites in complex biological matrices using LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a tracer to investigate absorption, distribution, metabolism, and excretion (ADME) pathways, enabling detailed metabolic stability and profiling studies.
• Mass Spectrometry Reference: Provides a definitive reference for method development and validation in mass spectrometric assays due to its predictable mass shift.
• Pharmacological Research: Supports research into the mechanism of action of topoisomerase I inhibitors and the impact of deuteration on biological activity.
• Impurity Identification and Characterization: Aids in the identification and structural elucidation of process-related impurities and degradation products during drug substance development.

Basic Information

Product Name	Belotecan-D7 Hydrochloride
CAS No.	1346598-22-8
Molecular Formula	C24H17D7ClN4O4 • HCl
Molecular Weight	Contact for details
Synonyms	7-Ethyl-10-hydroxycamptothecin-D7 hydrochloride; (S)-10-Hydroxy-7-ethyl-20(S)-camptothecin-D7 hydrochloride; CKD-602-D7 hydrochloride; Belotecan (heptadeuterated) hydrochloride; Camptothecin, 7-ethyl-10-hydroxy-, (20S)-, hydrochloride, labeled with deuterium (7 places)
EINECS	Contact for details

Quality Control

Our Belotecan-D7 Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and structural integrity. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), identity (by IR, NMR, MS), and other critical parameters is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storage under an inert atmosphere. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.