Description

2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinoline-D5 3-Aldehyde is a high-purity, deuterated aldehyde derivative of a quinoline-based scaffold, serving as a critical advanced intermediate in pharmaceutical research and development. Its core value lies in enabling precise metabolic and pharmacokinetic studies through the incorporation of stable deuterium atoms, which is essential for modern drug discovery programs. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and for use as an internal standard in analytical methods.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of deuterated drug candidates, leveraging the deuterium kinetic isotope effect (DKIE) to potentially improve metabolic stability and pharmacokinetic profiles.
• Metabolic Studies: Used as a labeled precursor or analog in Absorption, Distribution, Metabolism, and Excretion (ADME) studies to track and quantify drug metabolites.
• Analytical Reference Standard: Serves as a high-purity internal standard or reference compound in quantitative analytical techniques such as LC-MS (Liquid Chromatography-Mass Spectrometry) and NMR (Nuclear Magnetic Resonance) for method development and validation.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore the biological activity of novel quinoline derivatives targeting various disease pathways.
• Process Chemistry: Utilized in route scouting and optimization for the scalable synthesis of complex molecules containing the quinoline pharmacophore.
• Isotope Labeling: Provides a source of deuterium label for the preparation of other specifically labeled compounds used in mechanistic and tracer studies.

Basic Information

Product Name	2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinoline-D5 3-Aldehyde
CAS No.	1346597-84-9
Molecular Formula	C19H10D5FNO
Molecular Weight	~295.36 g/mol
Synonyms	2-Cyclopropyl-4-(4-fluorophenyl)quinoline-3-carbaldehyde-D5; 3-Formyl-2-cyclopropyl-4-(4-fluorophenyl)quinoline-D5; 2-Cyclopropyl-4-(p-fluorophenyl)quinoline-3-carboxaldehyde-D5; Deutero-labeled Quinoline Aldehyde; [D5]-2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinecarboxaldehyde; 4-(4-Fluorophenyl)-2-cyclopropylquinoline-3-carbaldehyde-D5; 1346597-84-9 (CAS Name-based Synonym)
EINECS	Contact for details

Quality Control

Our 2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinoline-D5 3-Aldehyde is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, essential for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as isotopic purity (D-enrichment), chemical purity by HPLC, and identity confirmation. We adhere to cGMP (current Good Manufacturing Practice) standards where applicable, and our quality systems are designed to meet the rigorous demands of pharmaceutical R&D and analytical laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize the risk of oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated place, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.