Description

1H-Indole-4-Carboxamide, 6-Bromo-n-[(1,2-Dihydro-4,6-Dimethyl-2-Oxo-3-Pyridinyl)Methyl]-3-Methyl-1-[(1S)-1-Methylpropyl]- is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in the development of small-molecule drugs, particularly within oncology and other specialized therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Oncology Drug Development: Employed in the research and development of potential kinase inhibitors and other targeted cancer therapies.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for studying novel heterocyclic compounds and their biochemical interactions.
• Process Chemistry: Acts as a standard or reference material during the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1H-Indole-4-Carboxamide, 6-Bromo-n-[(1,2-Dihydro-4,6-Dimethyl-2-Oxo-3-Pyridinyl)Methyl]-3-Methyl-1-[(1S)-1-Methylpropyl]-
CAS No.	1346574-54-6
Molecular Formula	C22H26BrN3O2
Molecular Weight	444.37 g/mol
Synonyms	6-Bromo-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-1H-indole-4-carboxamide; (S)-6-Bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-1-(sec-butyl)-1H-indole-4-carboxamide; 1H-Indole-4-carboxamide, 6-bromo-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-; CAS 1346574-54-6; Advanced Pharmaceutical Intermediate 1346574-54-6; Bromo-indole-pyridone carboxamide derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.