Description

Gsk872 is a high-purity, small molecule chemical compound with significant utility in advanced research and development. This compound is valued for its role as a potent and selective inhibitor of Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3), a key regulator of necroptosis and inflammatory pathways. It is primarily sought after by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in the study of cell death mechanisms, neuroinflammation, and related therapeutic areas. The product, identified as CAS NO 1346546-69-7, is supplied under stringent quality controls to ensure reliable and reproducible experimental results.

Application

• Biomedical Research: A critical tool for investigating the molecular mechanisms of necroptosis (programmed necrosis) and its role in various disease models.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in high-throughput screening and lead optimization for therapies targeting inflammatory and degenerative diseases.
• Neurological Disease Studies: Applied in preclinical research for conditions such as Amyotrophic Lateral Sclerosis (ALS), Alzheimer's disease, and multiple sclerosis where RIPK3-mediated pathways are implicated.
• Inflammatory Pathway Analysis: Facilitates the study of inflammation and immune response regulation in models of sepsis, ischemia-reperfusion injury, and inflammatory bowel disease.
• Academic & Institutional Research: Supports fundamental cell biology and biochemistry research in universities and government research institutes worldwide.
• Biomarker Development: Aids in the validation of RIPK3 as a potential therapeutic target and diagnostic biomarker.

Basic Information

Product Name	Gsk872
CAS No.	1346546-69-7
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	GSK'872; GSK-872; GSK872; 5-(1H-Indazol-5-yl)-N-(2-morpholin-4-ylethyl)-3H-[1,2,3]triazolo[4,5-b]pyrazin-7-amine; RIPK3 Inhibitor GSK872; Receptor-interacting serine/threonine-protein kinase 3 inhibitor GSK872; Necroptosis Inhibitor GSK872
EINECS	Contact for details

Quality Control

Every batch of Gsk872 is manufactured and analyzed under a strict quality management system to ensure the highest standards of purity and consistency for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.