Description

tert-Butyl Bis((3-Fluoropyridin-2-Yl)Methyl)Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected carbamate group and fluorinated pyridine moieties. This compound is critical for medicinal chemists as a versatile building block in the synthesis of complex bioactive molecules, particularly for drug discovery programs targeting neurological and oncological pathways. It is essential for research and development laboratories, custom synthesis providers, and pharmaceutical manufacturers requiring precise, high-quality intermediates for API development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluoropyridine and protected amine functionalities.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or component in the design of bifunctional degrader molecules.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the production of bespoke compounds and small-batch clinical trial materials.
• Agrochemical Research: Investigated as an intermediate for developing new generation pesticides and herbicides with improved efficacy.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	tert-Butyl Bis((3-Fluoropyridin-2-Yl)Methyl)Carbamate
CAS No.	1346447-11-7
Molecular Formula	C22H25F2N3O2
Molecular Weight	401.45 g/mol
Synonyms	Boc-Bis(3-Fluoro-2-pyridylmethyl)amine; tert-Butyl N,N-bis[(3-fluoropyridin-2-yl)methyl]carbamate; 1,1-Dimethylethyl N,N-bis[(3-fluoro-2-pyridinyl)methyl]carbamate; Carbamic acid, N,N-bis[(3-fluoro-2-pyridinyl)methyl]-, 1,1-dimethylethyl ester; BOC-Bis(3-Fluoropyridin-2-ylmethyl)amine; N-Boc-bis(3-fluoro-2-pyridylmethyl)amine; tert-Butyl bis(3-fluoro-2-pyridylmethyl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl Bis((3-Fluoropyridin-2-Yl)Methyl)Carbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.