Description

Arginase Inhibitor 1 CAS NO 1345808-25-4 is a potent and selective small molecule inhibitor of the arginase enzyme, a key target in metabolic and immunological research. This compound is essential for researchers investigating pathways related to urea cycle dysfunction, pulmonary hypertension, and tumor immunology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel therapeutics for cardiovascular, oncological, and inflammatory diseases.

Application

• Biomedical Research: Fundamental tool for studying the role of arginase in L-arginine metabolism and nitric oxide synthase (NOS) pathway regulation.
• Drug Discovery & Development: Key pharmacological agent in high-throughput screening (HTS) and lead optimization for arginase-targeted therapies.
• Oncology Research: Investigation of tumor microenvironment modulation, particularly in cancers where arginase activity suppresses T-cell function.
• Cardiovascular Disease Models: Used in preclinical studies for conditions like pulmonary arterial hypertension (PAH) and atherosclerosis.
• Immunology & Inflammation Studies: Probing macrophage polarization and the role of arginase in immune response and chronic inflammatory diseases.
• Metabolic Disorder Research: Exploration of urea cycle disorders and metabolic syndrome pathways.

Basic Information

Product Name	Arginase Inhibitor 1
CAS No.	1345808-25-4
Molecular Formula	C15H16N4O3
Molecular Weight	300.31 g/mol
Synonyms	2-(S)-Amino-6-boronohexanoic acid derivative; ABH derivative; Arginase Inhibitor I; BEC derivative; (S)-2-Amino-6-boronopentanoic acid, 5-(4-fluorophenyl)methyl ester; Nor-NOHA analog; Research Compound 1345808-25-4; Small Molecule Arginase Blocker
EINECS	Contact for details

Quality Control

Our Arginase Inhibitor 1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Potency (Enzymatic Assay)	IC50 ≤ 1 µM (vs. arginase)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.