Description

4-Bromo-5-Chloro-2-Fluorobenzotrifluoride is a high-value, multi-halogenated aromatic building block with a unique trifluoromethyl substituent, offering significant versatility in advanced organic synthesis. Its molecular structure is engineered to serve as a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce halogen and fluorine motifs for enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in areas like kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the halogen/fluorine pattern is crucial for efficacy.
• Material Science Precursor: Serves as a monomer or functionalization agent for creating specialty polymers and liquid crystals with specific electronic properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex aryl groups into target molecules.
• Fluorine Chemistry Research: An important substrate for studying the effects of polyhalogenation and trifluoromethylation on molecular properties.

Basic Information

Product Name	4-Bromo-5-Chloro-2-Fluorobenzotrifluoride
CAS No.	1345471-24-0
Molecular Formula	C7H2BrClF4
Molecular Weight	277.44 g/mol
Synonyms	2-Bromo-1-chloro-4-fluoro-5-(trifluoromethyl)benzene; 1-Bromo-2-chloro-5-fluoro-4-(trifluoromethyl)benzene; 4-Bromo-5-chloro-2-fluoro-α,α,α-trifluorotoluene; 2-Fluoro-4-bromo-5-chlorobenzotrifluoride; 5-Chloro-4-bromo-2-fluorobenzotrifluoride; Benzene, 2-bromo-1-chloro-4-fluoro-5-(trifluoromethyl)-; 4-Bromo-5-chloro-2-fluoro-1-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Chloro-2-Fluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.