Description

tert-Butyl 3-(Aminomethyl)-3-Fluoropiperidine- CAS NO 1345456-44-1 is a high-value, fluorinated piperidine derivative featuring both a protected amine and a fluorine atom on the same carbon center. This unique bifunctional structure makes it a critical advanced pharmaceutical intermediate (API) for medicinal chemistry research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets and enzyme inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination and amine functionalization on potency and pharmacokinetics.
• Agrochemical Synthesis: Employed in the development of novel pesticides and herbicides where the fluoropiperidine moiety can enhance biological activity and stability.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific, complex fluorinated heterocycles.

Basic Information

Product Name	tert-Butyl 3-(Aminomethyl)-3-Fluoropiperidine- CAS NO 1345456-44-1
CAS No.	1345456-44-1
Molecular Formula	C11H21FN2O
Molecular Weight	216.30 g/mol
Synonyms	1-Boc-3-(aminomethyl)-3-fluoropiperidine; tert-Butyl 3-(aminomethyl)-3-fluoropiperidine-1-carboxylate; 3-Fluoro-3-(aminomethyl)piperidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-(aminomethyl)-3-fluoropiperidine; 3-(Aminomethyl)-3-fluoropiperidine-1-carboxylic acid tert-butyl ester; 3-Fluoro-3-piperidinemethanamine, 1-(1,1-dimethylethoxy)carbonyl-; Boc-3-(aminomethyl)-3-fluoropiperidine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects with material produced under GMP-like conditions upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.