Description

cis-3-Fluoro-1-(3-Fluoropyridin-2-Yl)Cyclobutane-1-Carbonitrile is a high-purity, fluorinated cyclobutane derivative featuring a nitrile functional group. This compound is a critical advanced pharmaceutical intermediate (API) valued for its unique stereochemistry and fluorine atoms, which are essential for modulating the biological activity, metabolic stability, and lipophilicity of target drug molecules. It is primarily required by pharmaceutical R&D and manufacturing teams for the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorinated cyclobutane motifs.
• Agrochemical Development: Serves as a precursor for novel pesticides and herbicides, where the fluorine atoms enhance bioactivity and environmental stability.
• Ligand Synthesis: Employed in the development of specialized ligands for catalysis and molecular recognition applications.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination reactions and the properties of fluorinated alicyclic systems.

Basic Information

Item	Details
Product Name	cis-3-Fluoro-1-(3-Fluoropyridin-2-Yl)Cyclobutane-1-Carbonitrile
CAS No.	1344145-38-5
Molecular Formula	C10H7F2N2
Molecular Weight	193.17 g/mol
Synonyms	1-(3-Fluoro-2-pyridinyl)-3-fluorocyclobutanecarbonitrile, cis-; 3-Fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile; (1s,3s)-3-Fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile; (1R,3R)-3-Fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile; 1344145-38-5; cis-3-Fluoro-1-(3-fluoropyridin-2-yl)cyclobutanecarbonitrile; 2-(3-Fluoro-1-cyanocyclobutyl)-3-fluoropyridine
EINECS	Contact for details

Quality Control

Every batch of cis-3-Fluoro-1-(3-Fluoropyridin-2-Yl)Cyclobutane-1-Carbonitrile is manufactured under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards, including identity confirmation, purity analysis, and impurity profiling. Certificates of Analysis (COA) detailing lot-specific results from HPLC, NMR, and MS are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is sensitive to strong bases and fluorides; keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.