Description

Maytansine, N2'-Deacetyl-N2'-[3-[(1-Ethyl-2,5-Dioxo-3-Pyrrolidinyl)Thio]-1-Oxopropyl]- is a highly potent and sophisticated synthetic derivative of the natural cytotoxin maytansine, designed for targeted therapeutic applications. This compound is a critical intermediate in the development of Antibody-Drug Conjugates (ADCs), enabling the precise delivery of cytotoxic payloads to cancer cells. It is essential for pharmaceutical R&D teams and manufacturers focused on next-generation oncology treatments, particularly those developing novel ADCs and targeted chemotherapeutics.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a potent cytotoxic warhead for conjugation to monoclonal antibodies targeting specific tumor antigens.
• Oncology Drug Development: A key intermediate in the synthesis of advanced, targeted chemotherapeutic agents for clinical and preclinical research.
• Bioconjugation Research: Used in studies exploring novel linker technologies and conjugation strategies for improved drug delivery systems.
• Pharmaceutical Reference Standard: Employed as a high-purity analytical standard for quality control and method development in ADC manufacturing.
• Mechanistic Studies: Utilized in biochemical and pharmacological research to investigate microtubule inhibition and apoptosis induction.

Basic Information

Product Name	Maytansine, N2'-Deacetyl-N2'-[3-[(1-Ethyl-2,5-Dioxo-3-Pyrrolidinyl)Thio]-1-Oxopropyl]-
CAS No.	1343477-01-9
Molecular Formula	C36H47ClN4O9S2
Molecular Weight	779.36 g/mol
Synonyms	DM4-SPDB; N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine (DM1) derivative; Maytansinoid DM4 intermediate; SPDB-DM4; (3-((1-Ethyl-2,5-dioxopyrrolidin-3-yl)thio)-1-oxopropyl)-DM1; mertansine derivative; Tubulin inhibitor payload; ADC cytotoxic agent
EINECS	Contact for details

Quality Control

Our Maytansine derivative is manufactured under strict quality systems suitable for pharmaceutical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring the material meets the stringent requirements for ADC payload synthesis and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, maintain the material in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.