Description

1-(5-(Trifluoromethyl)Pyridin-2-Yl)Pyrrolidin-3-Ol is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique physicochemical properties imparted by the trifluoromethylpyridine and pyrrolidinol motifs, which are crucial for modulating the bioavailability and metabolic stability of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective targets.
• Agrochemical Synthesis: Serves as a critical building block for creating advanced herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Ligand and Catalyst Development: Used in the design of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Material Science Research: Investigated as a precursor for specialty polymers and advanced organic electronic materials due to its fluorine content and rigid structure.
• Chemical Biology Probe: Utilized in medicinal chemistry to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated scaffold.

Basic Information

Product Name	1-(5-(Trifluoromethyl)Pyridin-2-Yl)Pyrrolidin-3-Ol
CAS No.	1343181-22-5
Molecular Formula	C10H11F3N2O
Molecular Weight	232.20 g/mol
Synonyms	3-Hydroxy-1-[5-(trifluoromethyl)-2-pyridinyl]pyrrolidine; 1-[5-(Trifluoromethyl)pyridin-2-yl]pyrrolidin-3-ol; Pyrrolidin-3-ol, 1-[5-(trifluoromethyl)-2-pyridinyl]-; 2-(3-Hydroxypyrrolidin-1-yl)-5-(trifluoromethyl)pyridine; 1-(5-Trifluoromethyl-pyridin-2-yl)-pyrrolidin-3-ol
EINECS	Contact for details

Quality Control

Our 1-(5-(Trifluoromethyl)Pyridin-2-Yl)Pyrrolidin-3-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, we recommend keeping the material at 2-8°C under an inert atmosphere to maintain optimal stability. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.