Description

2-Oxo-1-(2,2,2-Trifluoroethyl)-1,2-dihydropyridine-3-carboxylic acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridone core and trifluoroethyl substituent. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in areas such as kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs).
• Kinase Inhibitor Synthesis: Serves as a core scaffold or precursor in the production of potential kinase inhibitor candidates for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes in drug discovery.
• Chemical Reference Standard: Employed as an analytical standard for quality control and method development in pharmaceutical analysis.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and complex organic molecules.
• Agrochemical Research: Potential intermediate in the development of new agrochemicals due to its heterocyclic structure.

Basic Information

Item	Details
Product Name	2-Oxo-1-(2,2,2-Trifluoroethyl)-1,2-Dihydropyridine-3-Carboxylic Acid
CAS No.	1341455-73-9
Molecular Formula	C8H6F3NO3
Molecular Weight	221.14 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 1,2-dihydro-1-(2,2,2-trifluoroethyl)-2-oxo-; 2-Oxo-1-(trifluoroethyl)-1,2-dihydronicotinic acid; 1-(Trifluoroethyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid; 2-Oxo-1-(2,2,2-trifluoroethyl)-1,2-dihydro-3-pyridinecarboxylic acid; 2-Oxo-1-(trifluoroethyl)-1,2-dihydropyridine-3-carboxylic acid; 3-Carboxy-1-(2,2,2-trifluoroethyl)-2-pyridone; 1-(2,2,2-Trifluoroethyl)-2-pyridone-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-Oxo-1-(2,2,2-Trifluoroethyl)-1,2-dihydropyridine-3-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), related substances, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.