Description

3-Azaspiro[5.5]Undecane-3-Sulfonyl Chloride is a specialized, high-value sulfonyl chloride derivative used as a key synthetic building block. Its value lies in its unique spirocyclic structure, which provides a rigid, three-dimensional scaffold for constructing complex molecules in medicinal chemistry. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in the development of protease inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its spirocyclic core for enhanced biological activity and selectivity.
• Chemical Biology Probe Synthesis: Employed to create activity-based probes (ABPs) for studying enzyme function and mechanism in biological systems.
• Peptidomimetic Chemistry: Serves as a constrained scaffold to mimic peptide structures, improving metabolic stability and bioavailability in drug design.
• Material Science Precursor: Potential use in the synthesis of specialized polymers or functionalized surfaces requiring specific sulfonamide linkages.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific research and scale-up projects.

Basic Information

Product Name	3-Azaspiro[5.5]Undecane-3-Sulfonyl Chloride
CAS No.	1340329-50-1
Molecular Formula	C10H18ClNO2S
Molecular Weight	251.77 g/mol
Synonyms	3-Azaspiro[5.5]undecane-3-sulfonyl chloride; 3-Azaspiro[5.5]undecane-3-sulfonoyl chloride; 3-Sulfonylchloride-3-azaspiro[5.5]undecane; 3-Chlorosulfonyl-3-azaspiro[5.5]undecane; Azaspiro[5.5]undecane-3-sulfonyl chloride; Spiro[5.5]undecane-3-sulfonyl chloride derivative; 3-Azaspiro[5.5]undecanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (NMR, IR), and impurity profiles are available upon request. We adhere to strict in-house quality protocols suitable for non-GMP pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a sulfonyl chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition from atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.