Description

Eg5-I CAS NO 1338701-15-7 is a potent and selective small-molecule inhibitor of the kinesin spindle protein Eg5, a critical target in oncology research. This compound matters for its role in disrupting mitotic spindle formation, leading to cell cycle arrest and apoptosis in rapidly dividing cells. It is primarily needed by pharmaceutical R&D teams and academic researchers focused on developing novel anti-cancer therapeutics and studying mitotic mechanisms.

Application

• Anticancer Drug Discovery: A key research tool for screening and validating Eg5 as a therapeutic target in various cancer cell lines.
• Mechanistic Biology Studies: Used to investigate the role of kinesin motor proteins in mitosis, spindle dynamics, and cell division.
• Preclinical Development: Serves as a lead compound or reference standard in the preclinical evaluation of novel anti-mitotic agents.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro enzymatic assays to measure Eg5 inhibition.
• Chemical Probe: Utilized as a selective chemical probe to dissect Eg5-specific pathways and their phenotypic consequences.

Basic Information

Product Name	Eg5-I
CAS No.	1338701-15-7
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	Eg5 Inhibitor I; (S)-5-Chloro-1-ethyl-2-((1-(4-(piperazin-1-yl)phenyl)ethyl)amino)-1H-benzo[d]imidazole-7-carboxamide; Kinesin Spindle Protein Inhibitor Eg5-I; KSP Inhibitor Eg5-I; Monastrol analog; (+)-Monastrol analog; ARRY-520 analog; Ispinesib-related compound
EINECS	Contact for details

Quality Control

Our Eg5-I is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance in your assays.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.