Description

Gsk2656157 CAS NO 1337532-29-2 is a potent and selective small molecule inhibitor of the protein kinase PERK (PKR-like endoplasmic reticulum kinase). This compound matters as a critical research tool for investigating the unfolded protein response (UPR) pathway, which is implicated in cellular stress, cancer biology, and neurodegenerative diseases. It is needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, metabolic disorders, and neuropharmacology.

Application

• Biomedical Research: Used as a selective chemical probe to study the role of PERK in the endoplasmic reticulum stress response and apoptosis.
• Oncology Studies: Investigated in preclinical research for its potential to sensitize cancer cells to chemotherapy by inhibiting pro-survival UPR signaling.
• Neurodegenerative Disease Models: Applied in research models of Alzheimer's, Parkinson's, and other diseases to understand PERK-mediated neuronal death pathways.
• Metabolic Disorder Research: Utilized in studies exploring the link between ER stress, PERK activation, and conditions like diabetes.
• Cell Signaling Pathway Analysis: A key reagent for dissecting the complex interplay between the UPR and other cellular signaling networks.
• Drug Discovery & Development: Serves as a reference compound or starting point for the development of novel PERK-targeting therapeutics.

Basic Information

Product Name	Gsk2656157
CAS No.	1337532-29-2
Molecular Formula	C₂₃H₂₀N₄O₃
Molecular Weight	400.43 g/mol
Synonyms	GSK2656157; GSK-2656157; 4-(2-Chloro-5-methoxyphenyl)-N-[(1S)-1-(5-cyano-2-pyridinyl)ethyl]-6-methyl-2-pyrimidinamine; PERK Inhibitor I; PERK Inhibitor GSK2656157; GSK 2656157; 1337532-29-2
EINECS	Contact for details

Quality Control

Our Gsk2656157 is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spectrometry)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.