Description

4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzene-1-Sulfonyl Fluoride is a high-value organoboron building block and sulfonyl fluoride reagent, critical for modern synthetic chemistry. Its dual functionality enables efficient, selective reactions, making it indispensable for constructing complex molecular architectures. This compound is primarily sought by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for applications in drug discovery, chemical biology, and advanced polymer synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: The boronate ester moiety serves as a key coupling partner for the synthesis of biaryl and heterobiaryl structures, a cornerstone in medicinal chemistry.
• Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry: The sulfonyl fluoride group is a prime electrophile for this next-generation click chemistry, enabling the reliable and modular construction of sulfonate esters and sulfamides under mild conditions.
• Proteomics and Chemical Biology: Used to develop covalent inhibitors and activity-based probes (ABPs) that selectively target serine hydrolases and other enzymes, facilitating target identification and validation.
• Pharmaceutical Intermediate: Acts as a versatile synthon for introducing both aryl-boronate and sulfonyl fluoride functionalities into potential drug candidates, particularly for kinase inhibitors and bioactive sulfonamides.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides and fungicides that incorporate sulfonamide or biaryl motifs.
• Polymer and Materials Science: Useful for creating functionalized monomers and cross-linkers to engineer polymers with specific thermal, mechanical, or surface properties.

Basic Information

Product Name	4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzene-1-Sulfonyl Fluoride
CAS No.	1337505-77-7
Molecular Formula	C12H16BFO4S
Molecular Weight	286.13 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl fluoride; p-(Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl fluoride; 1-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-sulfonylfluorobenzene; 4-Borono-1-sulfonylfluorobenzene pinacol ester; 4-Pinacolatoborylbenzenesulfonyl fluoride; 4-BMBS-F (common abbreviation); 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenylsulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzene-1-Sulfonyl Fluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including NMR (1H, 13C, 19F, 11B), HPLC for purity assessment, and mass spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Recommended storage temperature is 2-8°C for prolonged shelf life.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical: 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.