Description

Mito-Tempo CAS NO 1334850-99-5 is a mitochondria-targeted derivative of the stable nitroxide radical TEMPO, designed as a potent superoxide dismutase (SOD) mimetic and antioxidant. This compound is critically important for research focused on mitigating oxidative stress and mitochondrial dysfunction, which are central to numerous disease models and aging studies. It is an essential research-grade chemical for pharmaceutical R&D, academic institutions, and biotechnology companies investigating neurodegenerative diseases, cardiovascular conditions, and metabolic disorders.

Application

• Biomedical Research: Used as a targeted antioxidant to study the role of mitochondrial reactive oxygen species (ROS) in cellular aging, apoptosis, and signal transduction pathways.
• Pharmaceutical Development: Serves as a key reference standard and pharmacologically active compound in preclinical studies for drugs targeting oxidative stress-related conditions.
• Neurobiology Studies: Applied in models of neurodegenerative diseases (e.g., Alzheimer's, Parkinson's) to assess the protective effects against neuronal damage caused by mitochondrial oxidative stress.
• Cardiovascular Research: Utilized to investigate ischemia-reperfusion injury and other cardiac conditions where mitochondrial ROS generation is a contributing factor.
• Metabolic Disorder Research: Employed in studies of diabetes, obesity, and non-alcoholic fatty liver disease to understand the link between mitochondrial function and metabolic health.
• Anti-Aging Research: A critical tool in gerontology to explore interventions that improve mitochondrial health and extend cellular lifespan.
• Cell Culture & In Vitro Assays: Provides a reliable means to modulate redox environment in cell-based experiments to dissect specific mechanisms of oxidative damage.

Basic Information

Product Name	Mito-Tempo
CAS No.	1334850-99-5
Molecular Formula	C₂₅H₄₅N₂O₃P⁺
Molecular Weight	452.62 g/mol
Synonyms	(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-yl)-triphenylphosphonium; MitoTEMPO; Mito-TEMPO; Mitochondria-targeted TEMPO; 4-((2,2,6,6-Tetramethylpiperidin-1-oxyl-4-yl)oxy)-4-oxobutyl)triphenylphosphonium; TPTP; Mito-Tempo free radical.
EINECS	Contact for details

Quality Control

Our Mito-Tempo is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided, documenting the exact specifications for your records and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and efficacy.

Specification

Item	Specification
Appearance	Orange to red powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.