Description

6-Ethoxy-5-Fluoropyridine-3-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. This compound matters as a key Suzuki-Miyaura cross-coupling reagent, enabling the efficient construction of complex fluorinated pyridine derivatives. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing novel active ingredients and functional molecules. Its unique structure offers precise control in creating sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing fluorinated drug candidates, particularly in kinase inhibitor and CNS-active molecule research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a boronic ester coupling partner for introducing the 6-ethoxy-5-fluoropyridin-3-yl moiety into complex molecules.
• Chemical Biology Probes: Used to create fluorinated analogs of bioactive molecules for mechanism-of-action and target engagement studies.
• Library Synthesis: Enables high-throughput parallel synthesis for medicinal chemistry and structure-activity relationship (SAR) exploration.

Basic Information

Product Name	6-Ethoxy-5-Fluoropyridine-3-Boronic Acid Pinacol Ester
CAS No.	1334167-86-0
Molecular Formula	C13H19BFNO3
Molecular Weight	267.11 g/mol
Synonyms	5-Fluoro-6-ethoxypyridine-3-boronic acid pinacol ester; (6-Ethoxy-5-fluoropyridin-3-yl)boronic acid pinacol ester; 3-Borono-5-fluoro-6-ethoxypyridine pinacol ester; 6-Ethoxy-5-fluoro-3-pyridineboronic acid pinacol ester; 5-Fluoro-6-ethoxy-3-pyridinylboronic acid pinacol ester; 1334167-86-0; 6-Ethoxy-5-fluoropyridin-3-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 6-Ethoxy-5-Fluoropyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and GC for residual solvent analysis, to ensure high batch-to-batch consistency and compliance with customer specifications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged procedures to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.