Description

Nav1.7-In-2 is a potent and selective small molecule inhibitor of the voltage-gated sodium channel Nav1.7. This compound is of significant interest for its role as a key research tool in neuropharmacology and pain research, enabling the study of channel function and signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on developing novel analgesics and understanding neuropathic pain mechanisms.

Application

• Neuroscience Research: A critical tool for in vitro and in vivo studies investigating the role of Nav1.7 channels in pain signaling and neuronal excitability.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in high-throughput screening (HTS) and lead optimization campaigns for novel non-opioid pain therapeutics.
• Mechanistic Studies: Facilitates the exploration of sodium channel biology, including structure-activity relationships (SAR) and subtype selectivity profiles.
• Academic & Institutional Research: Supports fundamental research in university and government laboratories studying ion channel disorders and electrophysiology.
• Biotech & CRO Services: Employed in contract research for client projects targeting ion channels, providing essential data for preclinical development.

Basic Information

Product Name	Nav1.7-In-2
CAS No.	1332295-35-8
Molecular Formula	C23H25N5O3S
Molecular Weight	451.54 g/mol
Synonyms	PF-05089771; PF05089771; 5-[[(2,4-Dimethoxyphenyl)methyl]amino]-2-(2-methylpropyl)-3-pyridinecarbothioamide; Nav1.7 Inhibitor PF-05089771; Nav1.7 blocker; Sodium Channel Nav1.7 Inhibitor; (5-{[(2,4-Dimethoxyphenyl)methyl]amino}-2-isobutylpyridin-3-yl)carbothioamide
EINECS	Contact for details

Quality Control

Our Nav1.7-In-2 is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant standards for research chemicals, and specifications can be aligned with client requirements for advanced development stages.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.