Description

Pi3Kδ Inhibitor 1 is a potent and selective small molecule inhibitor of the phosphoinositide 3-kinase delta isoform, a key signaling node in immune cell function. This compound is a critical research tool for investigating the role of PI3Kδ in inflammatory and autoimmune diseases, as well as in certain hematological malignancies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel immunomodulatory and oncological therapeutics.

Application

• Biochemical Research: Used as a selective tool compound to study PI3Kδ signaling pathways in cellular and enzymatic assays.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of new PI3Kδ-targeted therapies for autoimmune conditions like rheumatoid arthritis and asthma.
• Oncology Research: Investigated for its potential role in B-cell malignancies, such as chronic lymphocytic leukemia (CLL), where PI3Kδ signaling is often dysregulated.
• Immunology Studies: Applied in vitro and in vivo to dissect the function of PI3Kδ in immune cell activation, proliferation, and migration.
• High-Throughput Screening (HTS): Employed as a control or validation compound in screening campaigns for PI3Kδ inhibitor discovery.

Basic Information

Product Name	Pi3Kδ Inhibitor 1
CAS No.	1332075-63-4
Molecular Formula	C₂₀H₂₀N₈O₂
Molecular Weight	404.43 g/mol
Synonyms	IC-87114; 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one; Quinazolinone, 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-(2-methylphenyl)-4(3H)-one; PI3K delta Inhibitor IC-87114; PI3Kδ Inhibitor IC87114; IC 87114; PI3Kδ Inhibitor 1 (IC-87114)
EINECS	Contact for details

Quality Control

Our Pi3Kδ Inhibitor 1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards. We support cGMP-compliant production for advanced development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.