Description

L-Citrulline-D6 is a stable isotope-labeled analog of the amino acid L-citrulline, where six hydrogen atoms are replaced by deuterium. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical research. It is a critical tool for scientists and quality control professionals in pharmaceutical development, clinical diagnostics, and advanced metabolic research who require definitive data for pharmacokinetic studies and biomarker quantification.

Application

• Quantitative Mass Spectrometry (LC-MS/MS, GC-MS): Serves as a crucial internal standard for the precise and accurate quantification of endogenous L-citrulline in complex biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic and Bioavailability Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion (ADME) for compounds affecting the nitric oxide or urea cycles.
• Clinical Diagnostics and Biomarker Research: Used in assays to measure L-citrulline levels as a potential biomarker for endothelial function, cardiovascular health, and certain metabolic disorders.
• Drug Metabolism and Metabolomics: Facilitates the study of metabolic pathways, including the urea cycle and nitric oxide synthase activity, in both in vitro and in vivo research settings.
• Quality Control and Method Validation: Provides a reference standard for validating analytical methods in pharmaceutical quality control laboratories, ensuring method robustness and compliance.
• Stable Isotope Tracer Studies: Employed in metabolic flux analysis to trace the incorporation of citrulline into other metabolites within biochemical pathways.

Basic Information

Product Name	L-Citrulline-D6
CAS No.	1331908-61-2
Molecular Formula	C₆H₇D₆N₃O₃
Molecular Weight	182.22 g/mol
Synonyms	(2S)-2-Amino-5-(carbamoylamino)-5,5,6,6,6-pentadeuteriopentanoic acid; L-2-Amino-5-ureidopentanoic-5,5,6,6,6-d5 acid; Citrulline-d6; (S)-2-Amino-5-ureidovaleric-5,5,6,6,6-d5 acid; δ-Ureidonorvaline-d6; N5-(Aminocarbonyl)ornithine-d6; Stable Isotope Labeled L-Citrulline
EINECS	Contact for details

Quality Control

Our L-Citrulline-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical standards. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and absence of impurities. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.