Description

Nordoxepin-D3 Hcl is a deuterium-labeled analog of the tricyclic antidepressant nortriptyline, specifically designed for use as an internal standard in analytical chemistry. This high-purity reference material is critical for ensuring accurate quantification and method validation in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units engaged in advanced pharmacokinetic studies and drug metabolism research.

Application

• Liquid Chromatography-Mass Spectrometry (LC-MS/MS) Internal Standard: Essential for the precise quantification of nortriptyline and its metabolites in plasma, serum, and urine samples.
• Pharmacokinetic and Bioequivalence Studies: Used to track drug absorption, distribution, metabolism, and excretion (ADME) with high accuracy.
• Forensic and Clinical Toxicology: Enables reliable detection and measurement of tricyclic antidepressant levels in diagnostic and legal contexts.
• Drug Metabolism Research: Facilitates the identification and study of metabolic pathways and potential drug-drug interactions.
• Quality Control in Pharmaceutical Manufacturing: Serves as a critical reference standard for in-process testing and final product release assays.
• Academic and Institutional Research: Supports investigative studies in neuropharmacology and analytical method development.

Basic Information

Product Name	Nordoxepin-D3 Hcl
CAS No.	1331665-54-3
Molecular Formula	C19H18D3ClN
Molecular Weight	299.86 g/mol
Synonyms	10,11-Dihydro-N-(3-methylaminopropyl)-5H-dibenzo[a,d]cycloheptene-5-propanamine-D3 Hydrochloride; Nortriptyline-D3 Hydrochloride; Desmethylamitriptyline-D3 HCl; (E)-3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine-D3 Hydrochloride; Nor-Doxepin-D3 HCl; 5-(3-(Methylamino)propylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-D3 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Nordoxepin-D3 Hcl is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, confirmed by advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, isotopic enrichment, and all relevant spectroscopic data to support your regulatory submissions and internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0% D3
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.