Description

(2E)-Dehydro Propafenone-D5 Hydrochloride CAS NO 1331643-41-4 is a deuterated isotopologue of a key propafenone metabolite, specifically designed for use as an internal standard in quantitative bioanalytical methods. This high-purity reference material is critical for ensuring the accuracy and reliability of pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in drug development and therapeutic drug monitoring.

Application

• Internal Standard for LC-MS/MS: Essential for the precise quantification of dehydropropafenone and related metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles for propafenone.
• Bioanalytical Method Development and Validation: Serves as a critical component in developing robust, regulatory-compliant (FDA, EMA) analytical assays.
• Therapeutic Drug Monitoring (TDM): Supports the accurate measurement of active metabolite levels to optimize propafenone dosing for cardiac arrhythmia patients.
• Clinical Research: Used in clinical trials to monitor metabolite concentrations and assess inter-individual variability in drug metabolism.
• Impurity Profiling and Characterization: Aids in the identification and quantification of specific metabolite impurities in drug substance and product analysis.

Basic Information

Product Name	(2E)-Dehydro Propafenone-D5 Hydrochloride
CAS No.	1331643-41-4
Molecular Formula	C21H22D5ClNO3
Molecular Weight	Contact for details
Synonyms	5-Deuterio-2'-[2-hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone-d4 Hydrochloride
Dehydro Propafenone D5 HCl
Propafenone Metabolite D5 (Dehydro) Hydrochloride
5-Hydroxypropafenone-d5 Hydrochloride (related metabolite)
N-Despropylpropafenone-d5 Hydrochloride (related metabolite)
RS-62343-d5 (potential research code)
Deuterated Propafenone Internal Standard
EINECS	Contact for details

Quality Control

Every batch of (2E)-Dehydro Propafenone-D5 Hydrochloride is manufactured and tested under strict quality systems. We guarantee high chemical and isotopic purity to meet the exacting demands of quantitative mass spectrometry. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing batch-specific purity, isotopic enrichment, and analytical data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Enrichment)	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.