Description

(S)-(-)-Celiprolol-D9 Hydrochloride is a high-purity, deuterium-labeled internal standard critical for advanced analytical applications. This compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities that require precise and traceable reference materials for mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the precise quantification of Celiprolol in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in clinical and pre-clinical research.
• Drug Metabolism Research: Facilitates the identification and quantification of drug metabolites in metabolism and disposition studies.
• Bioanalytical Method Development & Validation: Serves as a critical component in developing and validating robust, GLP-compliant analytical methods.
• Regulatory Submissions: Supports data packages for regulatory authorities (e.g., FDA, EMA) requiring high-fidelity analytical data.
• Quality Control in Pharmaceutical Manufacturing: Can be used in impurity profiling and assay verification of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(S)-(-)-Celiprolol-D9 Hydrochloride
CAS No.	1330266-42-6
Molecular Formula	C20H24D9N3O4•HCl
Molecular Weight	~428.0 g/mol (for monoisotopic)
Synonyms	Celiprolol-d9 HCl; (S)-Celiprolol-D9 Hydrochloride; 3-[3-Acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-1,1-diethylurea-d9 Hydrochloride; (±)-Celiprolol-D9 HCl; N-[3-Acetyl-4-[3-[(tert-butyl)amino]-2-hydroxypropoxy]phenyl]-N',N'-diethylurea-d9 Hydrochloride; Selectol-d9 HCl; 1-(3-Acetyl-4-{3-[(tert-butyl)amino]-2-hydroxypropoxy}phenyl)-3,3-diethylurea-d9 Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of (S)-(-)-Celiprolol-D9 Hydrochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet stringent standards. Our quality commitment includes traceable documentation and full compliance with current industry best practices. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and identification data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.