Description

n-Nitrosopiperazine-D8 is a deuterium-labeled analog of n-nitrosopiperazine, a compound of significant interest in analytical and research chemistry. This stable isotope-labeled standard is crucial for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses. It is primarily utilized by analytical laboratories and research institutions in the pharmaceutical, environmental, and food safety sectors for method development, validation, and as an internal standard in trace-level detection.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of n-nitrosopiperazine and related nitrosamine impurities.
• Pharmaceutical Impurity Testing: Essential for method development and validation in compliance with regulatory guidelines (e.g., ICH M7, FDA, EMA) for the detection and control of genotoxic nitrosamine impurities in active pharmaceutical ingredients (APIs) and drug products.
• Metabolic and Pharmacokinetic Studies: Used as a tracer in deuterium-labeled form for studying the absorption, distribution, metabolism, and excretion (ADME) profiles of nitrosamine compounds.
• Environmental and Food Safety Analysis: Applied in analytical methods to detect and quantify nitrosamine contaminants in environmental samples, foodstuffs, and consumer products.
• Research and Method Development: A key reagent for academic and industrial research focused on nitrosamine chemistry, carcinogenicity studies, and the development of novel analytical techniques.
• Quality Control and Assurance: Employed in high-purity form to calibrate instruments and ensure the precision and accuracy of nitrosamine testing protocols within quality control laboratories.

Basic Information

Product Name	n-Nitrosopiperazine-D8
CAS No.	1330180-56-7
Molecular Formula	C4D8N3O
Molecular Weight	134.19 g/mol
Synonyms	1-Nitrosopiperazine-D8; Piperazine-1-nitrosamine-D8; Deuterated N-Nitrosopiperazine; N-Nitrosopiperazine-d8; N-NPZ-d8; Nitrosopiperazine (deuterated); [2H8]-N-Nitrosopiperazine; Perdeuterated n-nitrosopiperazine
EINECS	Contact for details

Quality Control

Our n-Nitrosopiperazine-D8 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D-atom %), chemical purity by HPLC, and identity confirmation. We support compliance with GMP/GLP guidelines for reference standards used in pharmaceutical impurity testing.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as indicated on the label or Certificate of Analysis. For long-term storage under inert atmosphere, consult the specific product data sheet.

Specification

Item	Specification
Appearance	Yellow to orange solid or solution
Identification (IR / NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Chemical Purity)
Isotopic Purity (D-atom %)	≥ 98%
Isotopic Enrichment (MS)	≥ 98% (D8)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.