Description

2-(Benzylmethylamino)-3',4'-Dihydroxyacetophenone-D3 is a deuterated derivative of a phenolic ketone compound, specifically labeled with three deuterium atoms. This deuteration is critical for enhancing metabolic stability and traceability in advanced research applications, providing a valuable tool for pharmacokinetic and mechanistic studies. It is primarily utilized by pharmaceutical R&D laboratories and analytical chemists working on drug discovery, metabolite identification, and as an internal standard in mass spectrometry.

Application

• Pharmaceutical Reference Standard: Serves as a certified internal standard for the quantitative analysis of its non-deuterated counterpart in bioanalytical methods (LC-MS/MS).
• Drug Metabolism and Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of pharmaceutical compounds.
• Metabolite Identification: Aids in the detection and structural elucidation of drug metabolites in complex biological matrices.
• Mechanistic Studies: Employed in research to understand enzymatic pathways and reaction mechanisms due to the kinetic isotope effect (KIE) imparted by deuterium.
• Process Chemistry & Quality Control: Acts as a critical tool in the development and validation of synthetic routes and analytical methods within GMP environments.

Basic Information

Product Name	2-(Benzylmethylamino)-3',4'-Dihydroxyacetophenone-D3
CAS No.	1330172-65-0
Molecular Formula	C16H14D3NO3
Molecular Weight	~274.33 g/mol
Synonyms	2-[(Benzylmethylamino)]-3',4'-dihydroxyacetophenone-d3; 1-[3,4-Dihydroxyphenyl]-2-(benzylmethylamino)ethanone-d3; 3',4'-Dihydroxy-2-(N-benzyl-N-methylamino)acetophenone-d3; Deuterated Adrenalone Derivative; N-Benzyl-N-methyl-3,4-dihydroxy-α-deuterio-phenethylamine-d2 ketone; BMDA-D3; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our deuterated compounds are produced under strict quality management systems to ensure high isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-content), chemical purity, and analytical data is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light brown solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.