Description

Des(1-Cyclohexanol) Venlafaxine-D6 is a high-purity, deuterium-labeled internal standard critical for modern analytical chemistry. This compound is specifically designed for the accurate quantification of venlafaxine and its metabolites in complex biological matrices, ensuring superior precision and reliability in data. It is an essential tool for pharmaceutical R&D, clinical research, and forensic toxicology laboratories requiring definitive analytical results. The product is supplied with comprehensive analytical documentation to support regulatory submissions and quality control protocols.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the precise LC-MS/MS or GC-MS quantification of venlafaxine and O-desmethylvenlafaxine in plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust assays for monitoring venlafaxine concentrations in patient samples to optimize dosing regimens.
• Forensic & Clinical Toxicology: Used in confirmatory testing for venlafaxine in cases of overdose, compliance monitoring, or post-mortem investigations.
• Pharmaceutical Quality Control: Applied in the impurity profiling and assay validation of venlafaxine active pharmaceutical ingredients (APIs) and finished dosage forms.
• Reference Material for Method Development: Provides a critical benchmark for developing, optimizing, and validating new analytical methods in compliance with FDA, EMA, and ICH guidelines.

Basic Information

Item	Detail
Product Name	Des(1-Cyclohexanol) Venlafaxine-D6
CAS No.	1330046-00-8
Molecular Formula	C17H21D6NO2
Molecular Weight	283.44 g/mol (Calculated)
Synonyms	O-Desmethylvenlafaxine-D6; ODV-D6; Desvenlafaxine-D6 (hexadeuterated); 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol-d6; (R/S)-O-Desmethylvenlafaxine-d6; Major Venlafaxine Metabolite-d6; Pristiq-d6 (labeled analog); WY-45233-d6
EINECS	Contact for details

Quality Control

Every batch of Des(1-Cyclohexanol) Venlafaxine-D6 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed via NMR, HPLC, and mass spectrometry to confirm structure, purity, and deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes to support your GLP and GMP compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Incorporation)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.