Description

n-Cyclohexyl-N'-[2-(tert-Butyl)Amino-3-Hydroxypropoxy]Phenylurea-D5 is a deuterated analog of a key pharmaceutical intermediate, offering a stable isotopic label for advanced research and development. This compound is critical for conducting mass spectrometry-based pharmacokinetic, metabolic, and bioanalytical studies with enhanced sensitivity and reliability. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on drug discovery and development, particularly for compounds within the β-blocker or related therapeutic classes.

Application

• Internal Standard for LC-MS/MS: Serves as a critical, non-interfering internal standard in quantitative bioanalysis for accurate measurement of the non-deuterated parent drug in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in mass spectrometry to trace and quantify drug metabolites, enabling detailed studies on absorption, distribution, metabolism, and excretion (ADME).
• Stable Isotope Labeling in Medicinal Chemistry: Provides a chemically identical but mass-distinguishable tag for mechanistic studies, metabolic pathway elucidation, and proteomics research.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities or degradation products during drug substance development and quality control.
• Clinical Research Assay Development: Essential for developing and validating robust, GLP-compliant analytical methods for clinical trial sample analysis.
• Reference Standard for Regulatory Submissions: Used to prepare calibrated reference standards required for method validation dossiers submitted to regulatory agencies like the FDA and EMA.

Basic Information

Product Name	n-Cyclohexyl-N'-[2-(tert-Butyl)Amino-3-Hydroxypropoxy]Phenylurea-D5
CAS No.	1329835-86-0
Molecular Formula	C20H27D5N3O3
Molecular Weight	~365.52 g/mol
Synonyms	1-Cyclohexyl-3-[4-[2-[(1,1-Dimethylethyl)amino]-3-hydroxypropoxy]phenyl]urea-d5; Deuterated Carteolol Related Compound D5; [2H5]-n-Cyclohexyl-N'-[2-(tert-Butyl)Amino-3-Hydroxypropoxy]Phenylurea; Deuterated β-Blocker Intermediate D5; Carteolol-d5 Impurity/Intermediate; 4-[2-(tert-Butylamino)-3-hydroxypropoxy]phenyl-cyclohexyl-urea-d5; (RS)-1-(tert-Butylamino)-3-[4-(cyclohexylcarbamoyl)phenoxy]propan-2-ol-d5
EINECS	Contact for details

Quality Control

Our deuterated compounds are manufactured under strict quality control protocols to ensure isotopic purity, chemical purity, and batch-to-batch consistency essential for analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for assay (HPLC), isotopic enrichment (NMR/MS), chemical purity, and identification. We support cGMP and ISO 9001 compliant manufacturing environments for research and regulatory-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.