Description

n-Deshydroxy Ciclopirox-D11 is a deuterated derivative of the antifungal agent ciclopirox, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments requiring precise measurement of the parent drug in complex biological matrices.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a stable isotope-labeled internal standard for the precise quantification of ciclopirox and its metabolites in bioanalytical studies.
• Pharmaceutical Research & Development: Supports drug metabolism and pharmacokinetics (DMPK) studies, bioavailability testing, and pre-clinical/clinical trial sample analysis.
• Forensic and Anti-Doping Analysis: Enables accurate detection and quantification of ciclopirox in forensic toxicology and sports anti-doping control.
• Method Development and Validation: Used to develop, optimize, and validate robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control and Assurance: Serves as a reference material for in-house quality control testing of pharmaceutical formulations containing ciclopirox.
• Environmental and Agricultural Testing: Potential application in trace analysis of antifungal agents in environmental samples.

Basic Information

Product Name	n-Deshydroxy Ciclopirox-D11
CAS No.	1329835-51-9
Molecular Formula	C12H8D11NO2
Molecular Weight	Approx. 230.3 g/mol
Synonyms	6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone-d11; Ciclopirox-d11; Ciclopirox (deuterated, n-Deshydroxy); 6-Cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one-d11; Perdeuterated Ciclopirox (n-Deshydroxy); Antifungal Internal Standard-d11; CPX-d11; Loprox-d11 (deuterated variant)
EINECS	Contact for details

Quality Control

Our n-Deshydroxy Ciclopirox-D11 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (by MS), and residual solvent content. We adhere to industry best practices suitable for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.