Description

Idazoxan-D4 Hydrochloride is a deuterated isotopologue of the selective α2-adrenoceptor antagonist, Idazoxan, where four hydrogen atoms are replaced with deuterium. This compound is a critical internal standard for the precise quantification of Idazoxan in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is an essential tool for researchers and quality control laboratories in the pharmaceutical and life sciences sectors, particularly those involved in neuropharmacology research, drug metabolism and pharmacokinetics (DMPK) studies, and bioanalytical method development.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the accurate LC-MS/MS quantification of Idazoxan in plasma, serum, and tissue homogenates.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables reliable measurement of drug concentration-time profiles in preclinical and clinical research on α2-adrenergic agents.
• Metabolite Identification & Profiling: Used in mass spectrometry to distinguish drug-derived metabolites from endogenous compounds, aiding in metabolic pathway elucidation.
• Method Development & Validation: A key component in establishing GLP-compliant, robust, and sensitive analytical methods for regulatory submissions.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay validation for Idazoxan-based active pharmaceutical ingredients (APIs).
• Neuroscience & Neuropharmacology Research: Facilitates precise measurement of drug levels in brain tissue for studies on adrenergic receptor function and related disorders.

Basic Information

Product Name	Idazoxan-D4 Hydrochloride
CAS No.	1329834-12-9
Molecular Formula	C11H9D4ClN2O2
Molecular Weight	252.73 g/mol
Synonyms	Idazoxan (phenyl-d4) hydrochloride; 2-(1,4-Benzodioxan-2-yl)-2-imidazoline-d4 hydrochloride; Idazoxan-d4 HCl; Idazoxan (phenyl-d4) HCl; RX 781094-d4 hydrochloride; 2-(1,4-Benzodioxan-2-yl)-4,5-dihydro-1H-imidazole-d4 hydrochloride; Idazoxan (2,3,6,7-d4) hydrochloride
EINECS	Contact for details

Quality Control

Our Idazoxan-D4 Hydrochloride is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and MS, to confirm identity, chemical purity, and deuterium enrichment. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic purity, and related substance analysis is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D4)	≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.