Description

Biprofen-D3 is a deuterated analog of the non-steroidal anti-inflammatory drug (NSAID) ibuprofen, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors who require precise drug quantification and metabolic studies.

Application

• Internal Standard for LC-MS/MS: Primary application as a high-purity internal standard for the accurate quantification of ibuprofen and its metabolites in biological matrices (plasma, serum, urine).
• Pharmaceutical R&D: Used in pharmacokinetic (PK), pharmacodynamic (PD), and bioequivalence studies to track drug absorption, distribution, metabolism, and excretion (ADME).
• Clinical Research: Enables precise monitoring of ibuprofen levels in patient samples for therapeutic drug monitoring (TDM) and clinical trial analysis.
• Forensic and Doping Control: Supports accurate detection and quantification of ibuprofen in forensic toxicology and anti-doping laboratories.
• Method Development and Validation: Critical for developing, validating, and ensuring the robustness of analytical methods in compliance with GLP and GCP guidelines.
• Metabolite Tracing: Facilitates advanced research into the metabolic pathways and biotransformation of ibuprofen using stable isotope tracing techniques.

Basic Information

Product Name	Biprofen-D3
CAS No.	1329833-67-1
Molecular Formula	C13H15D3O2
Molecular Weight	209.30 g/mol (approx.)
Synonyms	Ibuprofen-d3; (RS)-2-(4-Isobutylphenyl)propionic-3,3,3-d3 acid; 2-(4-Isobutylphenyl)propionic-d3 acid; Deutrated Ibuprofen; Ibuprofen (phenyl-d3); Ibuprofen Internal Standard-d3; α-Methyl-4-(2-methylpropyl)benzeneacetic-3,3,3-d3 acid
EINECS	Contact for details

Quality Control

Every batch of Biprofen-D3 is manufactured and analyzed under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, isotopic purity (D-enrichment), and analytical results are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.