Description

Atovaquone-D5 is a deuterated isotopologue of the antiparasitic drug atovaquone, specifically labeled with five deuterium atoms. This high-purity stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring precise and accurate measurement of atovaquone in complex biological matrices. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, drug metabolism research, and clinical trial support.

Application

• Internal Standard for LC-MS/MS analysis of atovaquone in biological samples (plasma, serum, tissue).
• Quantitative bioanalysis in Pharmacokinetic (PK) and Pharmacodynamic (PD) studies.
• Drug metabolism and disposition (DMPK) research to track the parent compound.
• Method development and validation for regulatory submissions to agencies like the FDA and EMA.
• Quality control and assurance in the manufacturing of atovaquone-based pharmaceuticals.
• Stable isotope dilution mass spectrometry for high-accuracy quantification.

Basic Information

Product Name	Atovaquone-D5
CAS No.	1329792-63-3
Molecular Formula	C22H14D5ClO3
Molecular Weight	369.86 g/mol (for C22H14D5ClO3)
Synonyms	2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone-d5; 2-(4-(4-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthalenedione-d5; Atovaquone (phenyl-d5); Atovaquone-d5 (phenyl-d5); BW566C80-d5; Mepron-d5; Wellvone-d5; Deuterated Atovaquone
EINECS	Contact for details

Quality Control

Every batch of Atovaquone-D5 is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as isotopic purity, chemical purity, and identity confirmation via advanced spectroscopic techniques.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 95.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.